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Meeting SummaryThe retinoblastoma tumor suppressor (RB1) was cloned over 20 years ago. It was discovered due to its role in the childhood eye cancer, retinoblastoma, but is now understood to be part of a pathway that is defective in most, if not all human cancers. Moreover, it is conserved in diverse organisms including mammals, plants, worms, and flies. The initial biological function ascribed to RB protein was cell cycle regulation, and the connection between RB, its relatives p107 (RBL1) and p130 (RBL2), and the E2f family of transcription factors is now text book material. But insight into other target proteins and RB functions has expanded furiously. RB has been linked with diverse processes including apoptosis, autophagy, senescence, genome stability, immunity, telomere function, stem cell biology, and the development of many cell types, including placental trophoblasts, neurons, muscle, epithelia, erythrocytes and many others. In view of its broad importance to human biology and human health, we felt it would be exciting to hold an international RB meeting to bring together leading and emerging experts in the field. We hope you will join us both to celebrate the advances in RB research and to discuss and debate the burning issues that lie ahead. Meeting Organizers 2009: Rod Bremner and Eldad Zacksenhaus This meeting is sponsored by:
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